Screening of Antioxidants from Medicinal Plants for Cardioprotective Effect against Doxorubicin Toxicity

Evaluation of the potential cardioprotective activity of some Saudi plants against doxorubicin toxicity.

Doxorubicin (DOX) is an anthracycline antibiotic widely used as a chemotherapeutic agent in the treatment of several tumours. However, its cardiac toxicity limits its use at maximum therapeutic doses. Most studies implicated increased oxidative stress as the major determinant of DOX cardiotoxicity. The local Saudi flora is very rich in a variety of plants of quite known folkloric or traditional...

Cardioprotective effect of lipistat against doxorubicin induced myocardial toxicity in albino rats.

Preventive role of lipistat against doxorubicin induced myocardial toxicity in rats has been reported. Cardiotoxicity was produced by doxorubicin administration (15 mg/kg for 2 weeks). Lipistat (350 mg/kg, orally) was administered as pretreatment for 2 weeks and then for 2 weeks alternated with doxorubicin. The general observations, mortality, histopathology, biomarker enzymes like lactate dehy...

Cardioprotective Effect of Naringin against Doxorubicin Induced Cardiomyopathy in Rats

Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats

OBJECTIVE The clinical use of doxorubicin, which is a strong antineoplastic agent, is limited due to its cardiotoxic side effects. Metformin is a drug with antihyperglycemic effects, and it has been shown to have a cardioprotective effect on left ventricular function in experimental animal models of myocardial ischemia. The present study investigated the cardioprotective effect of metformin in ...

Screening of Some Medicinal Plants for Antibacterial Activity against Conjunctivitis

Antibiotic resistance is a persistently emerging problem all over the world. The constituents of therapeutic plant extracts play a key role in antimicrobial drug discovery. Extracts of 36 medicinal plant species of Pakistan origin that belong to 33 genera and 24 families were tested against the bacterial strains Staphylococcus aureus and Pseudomonas aeruginosa. In addition the extracts of 23 pl...